The synthesis and biological properties of some 5-substituted-2'-deoxyuridines.

Walker Rt; Slater Mj; Jones As; Jan Balzarini; De Clercq Erik

Abstract

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The reaction of various nucleophiles with 5-vinyl-2'-deoxyuridine has been studied in an attempt to explain the in vitro toxicity of the compound. Attempts to synthesise pro-drugs of 5-vinyl- and 5-ethynyl-2'-deoxyuridine are described.

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