The scaffolding function of LSD1 controls DNA methylation in mouse ESCs
Article 2024 en
Authors
SM
Sandhya Malla
KK
Kanchan Kumari
CG
Carlos A. García‐Prieto
Abstract
1 min read
Lysine-specific histone demethylase 1 (LSD1), which demethylates mono- or di- methylated histone H3 on lysine 4 (H3K4me1/2), is essential for early embryogenesis and development. Here we show that LSD1 is dispensable for mouse embryonic stem cell (ESC) self-renewal but is required for mouse ESC growth and differentiation. Reintroduction of a catalytically-impaired LSD1 (LSD1
Cong Lyu, Jonathan D. Gilthorpe, Hailin Wang, Simone Sidoli, Andrea Mattevi, André Mateus, Manel Esteller, Ángel Román, Francesca Aguiló, Sandhya Malla, Kanchan Kumari, Carlos Martinez‐Gamero, Carlos A. García‐Prieto, Stephanie Stransky, Jonatan Caroli, Damiana Álvarez‐Errico, Paulina Avovome Saiki, Weiyi Lai
Catherine Creppe, Peggy Janich, Neus Cantariño, Marc Noguera-Julián, Vanesa Valero, Eva Musulen, Julien Douet, Melanija Posavec, Juan Martín‐Caballero, Lauro Sumoy, Luciano Di Croce, Salvador Aznar Benitah, Marcus Buschbeck
Panagiotis Ntziachristos, Aristotelis Tsirigos, G. Grant Welstead, Thomas Trimarchi, Sofia Bakogianni, Luyao Xu, Evangelia Loizou, Linda Holmfeldt, Alexandros Strikoudis, Bryan H. King, Jasper Mullenders, Jared Becksfort, Jelena Nedjic, Elisabeth Paietta, Martin S. Tallman, Jacob M. Rowe, Giovanni Tonon, Takashi Satoh, Laurens Kruidenier, Rab K. Prinjha, Akira Shizuo, Pieter Van Vlierberghe, Adolfo A. Ferrando, Rudolf Jaenisch,
María Berdasco, Consolación Melguizo, José Prados, Antonio Gómez, Miguel Alaminos, Miguel Ángel Pujana, Miguel López, Fernando Setién, Raúl Ortíz, Inma Zafra, Antonia Aránega, Manel Esteller
Discussion(0)
No comments yet. Be the first to comment.