The role of STK11/LKB1 in cancer biology: implications for ovarian tumorigenesis and progression

Jian Jian Kang; Stefania Gallucci; Jian Pan; Jonathan S. Oakhill; Elaine Sanij

doi:10.3389/fcell.2024.1449543

Abstract

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STK11 (serine-threonine kinase 11), also known as LKB1 (liver kinase B1) is a highly conserved master kinase that regulates cellular metabolism and polarity through a complex signaling network involving AMPK and 12 other AMPK-related kinases. Germline mutations in

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