The Role of Amyloid-β, tau, and<i>Apolipoprotein E</i>ε4 in Alzheimer Disease: How Is the Team Playing?

Massimo Filippi; Elisa Canu; Federica Agosta

doi:10.3174/ajnr.a3295

Abstract

1 min read

The distinctive histopathologic hallmarks of Alzheimer disease (AD) are the neuritic plaques and the neurofibrillary tangles (NFT). Albeit described for the first time by Alois Alzheimer in 1907, the relationship of these histologic abnormalities to the pathogenesis of AD is still unclear. An

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