The Proapoptotic Influenza A Virus Protein PB1-F2 Forms a Nonselective Ion Channel

Michael Henkel; David Mitzner; Peter Henklein; Franz‐Josef Meyer‐Almes; Anna Moroni; Mattia L. DiFrancesco; Leonhard M. Henkes; Michael Kreim; Stefan M. Kast; Ulrich Sigmar Schubert; Gerhard Thiel

doi:10.1371/journal.pone.0011112

Abstract

1 min read

The data support the idea that PB1-F2 is able to form protein channel pores with no appreciable selectivity in membranes and that the c-terminus is important for this function. This information could be important for drug development.

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