Parasite clearance rates are important measures of anti-malarial drug efficacy. They are particularly important in the assessment of artemisinin resistance. The slope of the log-linear segment in the middle of the parasite clearance curve has the least inter-individual variance and is the focus of therapeutic assessment. The factors affecting parasite clearance are reviewed. Methods of presentation and the approaches to analysis are discussed.
Julia C. Cutts, Katherine O’Flaherty, Sophie Zaloumis, Elizabeth A. Ashley, Jo-Anne Chan, Marie Onyamboko, Caterina Fanello, Arjen M. Dondorp, Nicholas Day, Aung Pyae Phyo, Mehul Dhorda, Mallika Imwong, Rick M. Fairhurst, Pharath Lim, Chanaki Amaratunga, Sasithon Pukrittayakamee, Tran Tinh Hien, Ye Htut, Mayfong Mayxay, M A Faiz, Eizo Takashima, Takafumi Tsuboi, James G. Beeson, François Nosten, J. A. Simpson, Sir Nicholas White, Freya J. I. Fowkes
Kyaw Myo Tun, Atthanee Jeeyapant, Mallika Imwong, Min Thein, S Aung, Tin Maung Hlaing, Prayoon Yuentrakul, Cholrawee Promnarate, Mehul Dhorda, Charles J. Woodrow, Arjen M. Dondorp, Elizabeth A. Ashley, Frank Smithuis, Sir Nicholas White, Nicholas Day
Jennifer A. Flegg, Philippe J. Guérin, François Nosten, Arjen M. Dondorp, Rick M. Fairhurst, Duong Socheat, Steffen Borrmann, Anders Björkman, Andreas Mårtensson, Mayfong Mayxay, Paul N. Newton, Delia Bethell, Youry Se, Harald Noedl, Abdoulaye Djimdé, Sir Nicholas White, Kasia Stepniewska
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