The KCNMB1 E65K variant is associated with reduced central pulse pressure in the community-based Framingham Offspring Cohort — Alyson Kelley-Hedgepeth (2008) | RDL Network
The KCNMB1 E65K variant is associated with reduced central pulse pressure in the community-based Framingham Offspring Cohort
Article 2008 en
Authors
AK
Alyson Kelley-Hedgepeth
IP
Inga Peter
MM
Maria Claudia Montefusco
Abstract
1 min read
A diminished augmented pressure in K-carriers suggests a reduced or delayed wave reflection and supports the hypothesis that E65K reduces arterial impedance mismatch in the arterial tree. Our findings in a middle-aged community-based cohort, if replicated, would support that E65K has a favorable effect on arterial function and pulsatile hemodynamic load.
Alyssa A. Torjesen, Leroy L. Cooper, Jian Rong, Martin G. Larson, Naomi M. Hamburg, Daniel Levy, Emelia Benjamin, Ramachandran S. Vasan, Gary F. Mitchell
Inga Peter, Alyson Kelley-Hedgepeth, Gordon S. Huggins, David E. Housman, Michael E. Mendelsohn, Joseph A. Vita, Ramachandran S. Vasan, Daniel Levy, Emelia Benjamin, Gary F. Mitchell
Xuzhi Wang, Yuankai Zhang, Chathurangi H Pathiravasan, Honghuang Lin, Belinda Borrelli, Nicole L. Spartano, Emelia Benjamin, David D. McManus, Martin G. Larson, Ramachandran S. Vasan, Naomi M. Hamburg, Joanne M. Murabito, Chunyu Liu, Gary F. Mitchell
Discussion(0)
No comments yet. Be the first to comment.