THE INFLUENCE OF SILK FIBROIN 3D SCAFFOLD COMPOSITION FOR IN VITRO BONE TISSUE ENGINEERING
Article 2010 en
Authors
CC
Cristina Correia
SB
Sarindr Bhumiratana
LY
Leping Yan
Abstract
1 min read
Scaffold composition, configuration and resulting properties critically affects tissue development. In this study, we evaluated the influence of silk fibroin concentration (6 or 17%) and correspondent processing method (aqueous or HFIP-derived) and three- dimensional scaffold structure (lamellar or porous, with distinct pore size) on bone tissue formation by osteogenic differentiation of human adipose tissue derived stem cells (hASC). We observed that very similar bone tissue was formed in all silk fibroin scaffold groups, evaluated by alkaline phosphatase activity, calcium production, collagen type I deposition and scaffold bone volume fraction.
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