Atherosclerosis is the cause of morbiditiy for 70% of patients with type 2 diabetes. In both of these diseases, a protein complex known as the inflammasome is stimulated to activate interleukin-1β (IL-1β) and IL-18, which are pathogenic inflammatory cytokines. Triggers for the inflammasome are obesity-related factors, such as cholesterol crystals in atherosclerosis, or hyperglycemia, ceramides, and islet amyloid polypeptide in type 2 diabetes. Therapeutics that target IL-1β in clinical trials for type 2 diabetes might also decrease the incidence of atherosclerosis.
Meghana Patel, William G. Bernard, N Milev, William P. Cawthorn, Nichola Figg, Dan Hart, Xavier Prieur, Sam Virtue, Krisztina Hegyi, Stéphanie Bonnafous, Béatrice Bailly-Maître, Yajing Chu, Julian L. Griffin, Ziad Mallat, Robert V. Considine, Albert Tran, Philippe Gual, Osamu Takeuchi, Akira Shizuo, António Vidal-Puig, Martin R. Bennett, Jaswinder K. Sethi
Meghana Patel, William G. Bernard, N Milev, William P. Cawthorn, Nichola Figg, Dan Hart, Xavier Prieur, Sam Virtue, Krisztina Hegyi, Stéphanie Bonnafous, Béatrice Bailly-Maître, Yajing Chu, Julian L. Griffin, Ziad Mallat, Robert V. Considine, Albert Tran, Philippe Gual, Osamu Takeuchi, Akira Shizuo, António Vidal-Puig, Martin R. Bennett, Jaswinder K. Sethi
Meghana Patel, William G. Bernard, N Milev, William P. Cawthorn, Nichola Figg, Dan Hart, Xavier Prieur, Sam Virtue, Krisztina Hegyi, Stéphanie Bonnafous, Béatrice Bailly-Maître, Yajing Chu, Julian L. Griffin, Ziad Mallat, Robert V. Considine, Albert Tran, Philippe Gual, Osamu Takeuchi, Akira Shizuo, António Vidal-Puig, Martin R. Bennett, Jaswinder K. Sethi
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