The impact of irritant challenge on the skin barrier and myeloid-resident immune cells in women who are postmenopausal is modulated by hormone replacement therapy

Orsolya Kiss; Rajia Bahri; Rachel Watson; C P R Chike; A.K. Langton; Victoria Newton; Mike Bell; Christopher Em Griffiths; Silvia Bulfone‐Paus; Suzanne M. Pilkington

doi:10.1093/bjd/ljae226

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Christopher Em Griffiths

The impact of irritant challenge on the skin barrier and myeloid-resident immune cells in women who are postmenopausal is modulated by hormone replacement therapy

Article 2024 en

Authors

OK
Orsolya Kiss
RB
Rajia Bahri
RW
Rachel Watson

Abstract

1 min read

Individuals receiving HRT displayed enhanced skin barrier response to SLS challenge with thicker filaggrin and increased K10+ epidermal cell layers. Following challenge, HRT users exhibited elevated LC, inflammatory DC and macrophage counts in the dermis. These may render skin both more prone to inflammation and more capable of resolving it, while also promoting skin repair.

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The impact of irritant challenge on the skin barrier and myeloid-resident immune cells in women who are postmenopausal is modulated by hormone replacement therapy

Abstract

Discussion(0)

Related publications

365 The effect of irritant challenge on the skin barrier and myeloid resident immune cells in post-menopausal women is influenced by hormone replacement therapy

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[Adverse cardiovascular effects of postmenopausal hormone replacement therapy].