The immune profile induced is crucial to determine the effects of immunocastration over gonadal function, fertility, and GnRH‐I expression

Daniela Siel; Alexandra Loaiza; Sonia Vidal; Mario Caruffo; Rodolfo Paredes; Galia Ramírez‐Toloza; Lisette Lapierre; Cristóbal Briceño; Oliver Pérez; Leonardo Saénz

doi:10.1111/aji.12772

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Daniela Siel

The immune profile induced is crucial to determine the effects of immunocastration over gonadal function, fertility, and GnRH‐I expression

Article 2017 en

Authors

DS
Daniela Siel
AL
Alexandra Loaiza
SV
Sonia Vidal

Abstract

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Problem Immunocastration or vaccination against the GnRH‐I hormone is a promising alternative to reproductive control in different animal species. Given the low immunogenicity of this hormone, the use of adjuvants becomes necessary. Method of Study This study evaluated the effects of three adjuvants that induce different immune response profiles over gonadal function, fertility, and expression of GnRH‐I. Female mice (n = 6) were vaccinated at days 1 and 30 with a recombinant antigen for immunocastration and different adjuvants that induced preferentially Th1/Th2, Th2, and Th1 immune profiles. Results Th1/Th2 response is the most efficient to block reproductive activity in vaccinated animals, reducing the number of luteal bodies and pre‐ovulatory follicles. Th2 and Th1/Th2 responses induced an increase in GnRH‐I at the hypothalamus. Conclusion The immune profile induced by different adjuvants is essential on the effects over fertility, gonadal function, and hypothalamic GnRH‐I expression in immunocastrated animals.

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The immune profile induced is crucial to determine the effects of immunocastration over gonadal function, fertility, and GnRH‐I expression

Abstract

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The immune profile induced is crucial to determine the effects of immunocastration over gonadal function, fertility, and GnRH‐I expression

Abstract

Discussion(0)

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