The HTT gene influences plasma neurofilament light chain and brain metabolism in prodromal Alzheimer’s disease
Article 2025 en
Authors
SM
Salvatore Mazzeo
CC
Chiara Crucitti
ML
Michael Lassi
Abstract
1 min read
Among individuals with SCD and MCI who show evidence of AD pathology, CAG repeat length in the HTT gene below the HD pathological threshold is associated with biomarkers of neurodegeneration in a region-specific and U-shaped manner. These findings suggest a modulatory role of HTT in prodromal AD.
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