The Final Steps of Bacillaene Biosynthesis in <i>Bacillus amyloliquefaciens</i> FZB42: Direct Evidence for β,γ Dehydration by a <i>trans</i>‐Acyltransferase Polyketide Synthase — Jana Moldenhauer (2010) | RDL Network
The Final Steps of Bacillaene Biosynthesis in <i>Bacillus amyloliquefaciens</i> FZB42: Direct Evidence for β,γ Dehydration by a <i>trans</i>‐Acyltransferase Polyketide Synthase
Article 2010 en
Authors
JM
Jana Moldenhauer
DG
Daniel C. G. Götz
CA
Christian R. Albert
Abstract
1 min read
Caught in the act: Genetic pathway engineering in conjunction with HPLC–NMR spectroscopy of highly labile intermediates provided direct evidence for the installation of β,γ double bonds during polyketide elongation to form the antibiotic bacillaene. The novel congener bacillaene B (1) was also discovered as an elusive true end product of the pathway in Bacillus amyloliquefaciens.
Jana Moldenhauer, Daniel C. G. Götz, Christian R. Albert, Sebastian Bischof, Kathrin Schneider, Roderich D. Süßmuth, Marianne Engeser, Harald Gross, Gerhard Bringmann, Jörn Piel
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