The enzymatic oxidation of phenolic tetrahydroisoquinoline-1-carboxylic acids

I. G. C. Coutts; Michael R Hamblin; Edward J. Tinley; James M. Bobbitt

doi:10.1039/p19790002744

Abstract

1 min read

Tetrahydroisoquinoline-1-carboxylic acids with a 6- or 7-hydroxy substituent undergo oxidative decarboxylation on treatment with horseradish peroxidase or fungal laccase to give high yields of the corresponding 3,4-dihydroisoquinolines. Attempts to apply this reaction to the formation of an aporphine were unsuccessful.

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