Paradoxically, most if not all previously known appetite-stimulatory hormones are downregulated in human obesity, reflecting failing homeostatic circuitries. Recently, we discovered that acyl-coenzyme-A binding protein/diazepam-binding inhibitor (ACBP/DBI) acts as a lipogenic and appetite stimulator, when systemically injected into mice. ACBP/DBI plasma levels are also elevated in obese subjects, supporting the notion that it may represent the elusive "hunger protein" that explains overeating in human obesity.
Jasmina Mallet, D. Misdrahi, Émilie Olié, Christine Passerieux, Mircea Polosan, Paul Roux, Ludovic Samalin, Franck Schürhoff, Raymond Schwan, Chr̀istophe Magnan, Franck Oury, José Manuel Bravo‐San Pedro, Guido Guido Kroemer, Adrien Joseph, Stéphanie Moriceau, Valentina Sica, Gerasimos Anagnostopoulos, Jonathan Pol, Isabelle Martins, Antoine Lafarge, Maria Chiara Maiuri, Marion Leboyer, J. Loftus,
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