The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16INK4a

Therese M. Becker; Sebastian Haferkamp; M K Dijkstra; Lyndee L. Scurr; Monika Frausto; Eve Diefenbach; Richard A Scolyer; David Reisman; Graham J. Mann; Richard Kefford; Helen Rizos

doi:10.1186/1476-4598-8-4

Abstract

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This data adds to the increasing evidence implicating the SWI/SNF chromatin remodelling complex in tumour development and the association of p16INK4a with chromatin remodelling highlights potentially new functions that may be important in melanoma predisposition and chemoresistance.

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