The changes of neurohormones after endurance exercise training in the patients with chronic heart failure

Objective To investigate the effects of endurance exercise training on plasma arginine vasopressin,atrial natriuretic peptide,angiotensinⅡ and aldosterone levels in chronic heart failure patients.Methods 12 chronic heart failure patients (coronary heart disease,New York Heart Association classⅡorⅢ) underwent supervised endurance exercise training on alternate days during a 120 days period.Before and after endurance exercise training,these neurohormones were measured by radioimmunoassay in resting condition and after peak treadmill exercise.Results After endurance exercise training for 120 days,the resting neurohormones levels were reduced significantly(P0.05),but the plasma neurohormones levels after peak treadmill exercise did not change significantly(P0.05).Conclusion The endurance exercise training could reduce the resting plasma arginine vasopressin,atrial natriuretic peptide,angiotensinⅡand aldosterone levels in chronic heart failure patients.The reduction in circulating neurohormones may delay the progress of chronic heart failure.