The Activity of Chemotherapy in Inflammatory Myofibroblastic Tumors: A Multicenter, European Retrospective Case Series Analysis — Giacomo Giulio Baldi (2020) | RDL Network
The Activity of Chemotherapy in Inflammatory Myofibroblastic Tumors: A Multicenter, European Retrospective Case Series Analysis
Article 2020 en
Authors
GB
Giacomo Giulio Baldi
MB
Mehdi Brahmi
SV
Salvatore Lo Vullo
Abstract
1 min read
Inflammatory myofibroblastic tumor (IMT) is an ultrarare sarcoma with known sensitivity to anaplastic lymphoma kinase (ALK) inhibitors in ALK-fused cases, although ALK inhibitors are not licensed in the disease. The current knowledge on the activity of cytotoxic chemotherapy is limited. This multi-institutional retrospective study on pediatric and adult patients with IMT shows that cytotoxic chemotherapy, and in particular anthracycline-based and methotrexate plus/minus vinorelbine/vinblastine regimens, represents a treatment option and can be considered in IMT patients irrespectively from ALK status. This study provides a benchmark for future studies on new medical therapies.
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Che‐Jui Lee, Patrick Schöffski, Elodie Modave, Tom van Wezel, Bram Boeckx, Jozef Šufliarský, Hans Gelderblom, Jean Yves Blay, Maria Dêbiec‐Rychter, Raf Sciot, Judith V.M.G. Bovée, Diether Lambrechts, Agnieszka Woźniak
Agnieszka Woźniak, Che‐Jui Lee, Tom van Wezel, Jozef Šufliarský, Hans Gelderblom, Jean Yves Blay, Maria Dêbiec‐Rychter, Raf Sciot, Judith V.M.G. Bovée, Patrick Schöffski
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Roberta Sanfilippo, Robin L. Jones, Jean Yves Blay, Axel Le Cesne, Salvatore Provenzano, Γεώργιος Αντωνίου, Olivier Mir, Giovanni Fucá, Elena Fumagalli, Rossella Bertulli, Silvia Stacchiotti, Mehdi Brahmi, Federica Grosso, Armelle Dufresne, Nadia Hindi, Marta Sbaraglia, Alessandro Gronchi, Paola Collini, Angelo Paolo Dei Tos, Paolo G. Casali
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