Targeting Long Noncoding <scp>RNA H19</scp> in Subchondral Bone Osteocytes and the Alleviation of Cartilage Degradation in Osteoarthritis

In summary, our results provide new evidence that the elevated H19 expression in osteocytes may contribute to aberrant subchondral bone remodeling and OA progression. H19 appears to be required for the osteocyte response to mechanical stimulation, and targeting H19 represents a new promising approach for OA treatment.