Targeting complex IV to alter the tumor microenvironment and boost macrophage antitumor immunity

T. Joshua Pfefer; Luke O'neill

doi:10.1093/lifemeta/loaf032

Back

Targeting complex IV to alter the tumor microenvironment and boost macrophage antitumor immunity

Article 2025 en

Abstract

1 min read

. showcase that interferons (IFNs) trigger a functional reprogramming of tumor-associated macrophages (TAMs) by downregulating NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 4 (NDUFA4), a key subunit of mitochondrial complex Ⅳ. This drives a transition from protumor TAMs to antitumor IFN-associated TAMs (IFN-TAMs) through activation of the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway. This mechanism can be leveraged to boost antitumor immunity and improve responses to immune checkpoint blockade.

Discussion(0)

No comments yet. Be the first to comment.

Related publications

Article2023

Multifunctional Calcium–Manganese Nanomodulator Provides Antitumor Treatment and Improved Immunotherapy via Reprogramming of the Tumor Microenvironment

Guanghong Luo, Xing Li, Jihui Lin, Ge Gao, Jiangli Fang, Wangze Song, Gary Guishan Xiao, Bo Zhang, Xiaojun Peng, Yanhong Duo, Ben Zhong Tang

Article2024

Abstract 715: Nanomedicines loaded with TLR agonists and inhibitors of immunosuppression to reprogram the tumor microenvironment

Fernando Torres, Alba Pensado‐López, Clément Anfray, Aldo Ummarino, Iago Fernández‐Mariño, Lucía Sanjurjo, José Crecente‐Campo, Eduardo Fernández-Megía, Flávia Castro, María José Oliveira, Alfonso Calvo, Rosario García Campelo, Alberto Mantovani, Marı́a José Alonso, Paola Allavena

Dataset

Dataset related to article "Size-advantage of monovalent nanobodies against the macrophage mannose receptor for deep tumor penetration and tumor-associated macrophage targeting"

Marco Erreni, Francesca D’Autilia, Roberta Avigni, Evangelina Bolli, Sana M. Arnouk, Kiavash Movahedi, Pieterjan Debie, Achille Anselmo, Raffaella Parente, Cécile Vincke, Fihs W B van Leeuwen, Paola Allavena, Cecília Garlanda, Alberto Mantovani, Andrea Doni, Sophie Hernot, Jo A. Van Ginderachter

Dataset

Dataset related to article "Intratumoral combination therapy with poly(I:C) and resiquimod synergistically triggers tumor-associated macrophages for effective systemic antitumoral immunity "

Clément Anfray, Francesco Mainini, Elisabeth Digifico, Akihiro Maeda, Marina Sironi, Marco Erreni, Achille Anselmo, Aldo Ummarino, Sara Gandoy, Francisco Expósito, Miriam Redrado, Diego Serrano, Alfonso Calvo, Marvin Martens, Susana B. Bravo, Alberto Mantovani, Paola Allavena, Fernando Torres

Dataset

Dataset related to article "Intratumoral combination therapy with poly(I:C) and resiquimod synergistically triggers tumor-associated macrophages for effective systemic antitumoral immunity "