Targeted Downregulation of Extracellular Nephrin in Human IgA Nephropathy

Elena Gagliardini; Ariela Benigni; Susanna Tomasoni; Mauro Abbate; Raghu Kalluri; Giuseppe Remuzzi

doi:10.1159/000072281

Abstract

1 min read

These results indicate that the ultrastructure of the filtration slit diaphragm is altered in patients with IgA nephropathy as a consequence of targeted downregulation of extracellular nephrin. Further studies are needed to evaluate the pathophysiological meaning of nephrin abnormality in IgA nephropathy and how these changes can be modulated by antiproteinuric therapy.

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The Nephron journals/Nephron journals

Targeted Downregulation of Extracellular Nephrin in Human IgA Nephropathy

Abstract

Discussion(0)

Related publications

The antiproteinuric effect of angiotensin antagonism in human IgA nephropathy is potentiated by indomethacin.

Dataset related to: Empagliflozin protects glomerular endothelial cell architecture in experimental diabetes through the VEGF-A/caveolin-1/PV-1 signaling pathway

Dataset related to: Empagliflozin protects glomerular endothelial cell architecture in experimental diabetes through the VEGF-A/caveolin-1/PV-1 signaling pathway

Empagliflozin protects glomerular endothelial cell architecture in experimental diabetes through the <scp>VEGF‐A</scp> /caveolin‐1/ <scp>PV</scp> ‐1 signaling pathway

Increased Urinary Excretion of Macrophage-Colony-Stimulating Factor (M-CSF) in Patients with IgA Nephropathy: Tonsil Stimulation Enhances Urinary M-CSF Excretion