Synthesis of Taurine-Containing Peptides, Sulfonopeptides, and N- and O-Conjugates

Peter Vertesaljai; Suvendu Biswas; Iryna Lebedyeva; Evan Broggi; Abdullah Mohamed Asiri; Alan R. Katritzky

doi:10.1021/jo500181g

Abstract

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Taurine-containing water-soluble peptidomimetics were designed and synthesized. N-terminal taurine acylations allowed synthesis of a number of taurine-containing peptides. N-protection of taurine with Cbz and SO2-activation with benzotriazole followed by coupling with various amino esters, dipeptides and nucleophiles provided taurine N- and O-conjugates and sulfonopeptides.

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Synthesis of Taurine-Containing Peptides, Sulfonopeptides, and <i>N</i>- and <i>O</i>-Conjugates

Abstract

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Related publications

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