Synthesis of a Novel Class of Some 1,3,5-Triazine Derivatives and their Anti-HIV Activity

Novel substituted s-triazine based derivatives were prepared by condensation of 2,4,6-trichloro-1,3,5-s-triazine with anisole, p-trifluoromethyl aniline and amino acid chloride, upon which the compounds were derivatized to their phenyl(thio)urea derivatives, and evaluated for their antiviral activity against human immunodefiency virus HIV-1 (IIIB) and HIV-2 (ROD). The structures of novel synthesized compounds have been established on the basis of 1H NMR, FTIR spectral data and elemental analysis.