Synthesis, Anti-Tuberculosis and Antiviral Activity of Novel 2-isonicotinoylhydrazono-5-arylidene-4-thiazolidinones

This paper describes the synthesis and structural elucidation of some novel N'-[5-(substituted benzylidene)-3-alkyl-4-oxo-1,3-thiazolidin-2-ylidene]isonicotinohydrazides and evaluation of their chemotherapeutic potency. The most potent derivative demonstrated an IC90 value of 2.039 µg/ml and an IC50 value of 1.267 µg/ml against M. Tuberculosis H37Rv while one of our compounds inhibited cytopathicity of HIV-1 (IIIB) by 50% at 8.73 µg/ml and other two derivatives were found active against either thymidine kinase positive or deficient strains of varicella-zoster virus with IC50 values of 2.0 and 1.8 µg/ml.