Synthesis and biological evaluation of some new bipyrazolylbenzenesulfonamides as possible antimicrobial and chemotherapeutic agents

A series of functionalized bipyrazoles, fused bipyrazoles and other related heterocyclic systems have been synthesized. The key intermediate bipyrazoles have been prepared by cyclocondensation of the appropriate chalcone with 4hydrazinobenzenesulfonamide hydrochloride. The chemistry of the reactions employed in the synthesis of the target compounds together with their chemical behaviour, are discussed and the structures of the newly synthesized compounds have been confirmed by the IR and H and C NMR spectral data. All the synthesized compounds show weak anticancer activity and weak antimicrobial and antifungal activity against some bacteria and fungi.