Synthesis and Biological Evaluation of some 2,5-Disubstituted -1,3,4- Oxadiazole Derivatives

Synthesis of some new 2, 5-diaryl-1, 3, 4-oxadiazole derivatives starting from Isoniazide (INH) is described. The target compounds 11- 20 were obtained by treating INH with various aromatic aldehydes and monosaccharides to give corresponding Schiff ’s bases 1- 10, which upon subsequent oxidation, by using either method A, B or C, yielded desired compounds. They were purified and characterized by spectroscopic techniques and elemental analyses. These compounds were evaluated for antibacterial, antifungal and antiviral activities. Compounds 11, 16 and 17 exhibited good antibacterial and antifungal activity, however, none of the compounds were enough active against various strains of virus.