Synthesis and biological evaluation of 6-amino-1H-pyrrolo[3,2-c]pyridin-4(5H)-one (3,7-dideazaguanine)
Article 1984 en
Authors
SS
Stewart W. Schneller
JL
Jiann Kuan Luo
RH
Ramachandra S. Hosmane
Abstract
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The synthesis of 6-amino-1H-pyrrolo[3,2-c]pyridin-4(5H)-one (3,7-dideazaguanine, 2) has been accomplished from 3-(ethoxycarbonyl)pyrrole-2-acetonitrile. In contrast to 3-deazaguanine, compound 2 did not show any antitumor, antiviral, or antibacterial properties. Furthermore, it was not a substrate for hypoxanthine-guanine phosphoribosyltransferase or purine nucleoside phosphorylase.
Stewart W. Schneller, Junming Luo, Ramachandra S. Hosmane, De Clercq Erik, Johanna D. Stoeckler, Khushboo Agarwal, Robert E. Parks, Priscilla P. Saunders
Vedran Krištafor, Zoran Džolić, Mario Cetina, Ante Nagl, Antonija Hergold‐Brundić, Draginja Mrvoš Sermek, Thomas Burgemeister, Mira Grdiša, Neda Slade, Krešimir Pavelić, Jan Balzarini, De Clercq Erik, Mladen Mintas
Zoran Džolić, Vedran Krištafor, Mario Cetina, Ante Nagl, Antonija Hergold‐Brundić, Draginja Mrvoš‐Sermek, Thomas Burgemeister, Mira Grdiša, Neda Slade, Krešimir Pavelić, Jan Balzarini, De Clercq Erik, Mladen Mintas
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