SYNTHESIS AND BIOLOGICAL ACTIVITIES OF (<i>Z</i>) AND (<i>E</i>) α-ETHENYL ACYCLONUCLEOSIDES

N. Redwane; H. B. Lazrek; J. L. Barascut; Jean‐Louis Imbach; Jan Balzarini; Myriam Witvrouw; De Clercq Erik

doi:10.1081/ncn-100105239

Abstract

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Synthesis of Z and E ethenyl acyclonucleosides (6a-e and 7a-e) via Michael addition of nucleobases with the diethyl acetylenedicarboxylate is described. The structures of compounds have been confirmed by spectral data. New compounds were found to be inactive against DNA and RNA viruses.

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