Synthesis and Antiviral Properties of Aza-Analogues of<i>Acyclovir</i>

Wojciech Sas; De Clercq Erik; Mariola Koszytkowska‐Stawińska; Katarzyna Kaleta

doi:10.1080/15257770601052281

Abstract

1 min read

Aza-analogues of Acyclovir were obtained from N-(2-pivaloyloxyethyl)-N-(pivaloyloxymethyl)-p-toluenesulfonamide via a one-pot base silylation/nucleoside coupling procedure. The antiviral activities of all aza-nucleosides in vitro against a variety of viruses were evaluated. None of these compounds displayed any specific antiviral effects.

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