Synthesis and Antiviral Evaluation of Some 3′‐Fluoro Bicyclic Nucleoside Analogues

Christopher McGuigan; Antonella Carangio; Robert Snoeck; Graciela Andreï; De Clercq Erik; Jan Balzarini

doi:10.1081/ncn-120027813

Abstract

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The synthesis of 3'-fluoro analogues of recently discovered highly potent anti-VZV furanopyrimidine deoxynucleosides (BCNAs) is herein reported, for both the alkyl and alkylphenyl series. The compounds are tested against a range of herpes viruses and display poor activity, strongly supporting the notion of the importance of the presence of a 3'-OH for antiviral activity.

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