Synthesis and antiviral evaluation of several 6‐(Methylene‐carbomethoxy)pteridine‐4,7(3<i>H</i>,8<i>H</i>)‐diones

Abstract The reactions of 5,6‐diaminopyrimidin‐4(3 H )‐one derivatives 1a‐h , with dimethyl acetylenedicarboxylate are discussed in this paper. 6‐Amino‐5‐( E )(1′,2′‐dicarbomethoxyvinyl)aminopyrimidines, 2 , and 6‐(methylenecarbomethoxy)pteridinones, 3 , have been obtained as main the products, which can be explained on the basis of a Michael addition on pyrimidine derivatives, and cyclization. Those compounds were evaluated for their in vitro antiviral activity.