Synthesis and Antiviral Evaluation of Ribavirin Congeners Containing a Hexitol Moiety

Arthur Van Aerschot; Guy Schepers; Roger Busson; Johan Neyts; De Clercq Erik; Piet Herdewijn

doi:10.1081/ncn-120022669

Abstract

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Several ribavirin congeners containing a hexitol moiety were prepared via ring opening of two different epoxides with the methylcarboxylate ester of triazole and further elaboration. Unfortunately, none of the newly synthesized compounds displayed appreciable antiviral activity.

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