Synthesis and Antiviral Evaluation of N-β-D-Ribosides of Ergot Alkaloids

Vladimı́r Křen; A. Pískala; Petr Sedmera; Vladimír Havlíěek; Věra Přikrylová; Myriam Witvrouw; De Clercq Erik

doi:10.1080/07328319708002525

Abstract

1 min read

Abstract N-β-D-Ribosides of agroclavine (1), elymoclavine (2), lysergene (4), lysergol (3), and 9, 10-dihydrolysergol (5) were prepared by SnCl4 catalyzed ribosylation of their TMS derivatives with 1-O-acetyl-2, 3,5-tri-O-benzoyl-β-D-ribofuranose. None of the new compounds exhibited activity against HIV or other viruses tested.

Discussion(0)

No comments yet. Be the first to comment.

Related publications

Article1998

Quinolone Nucleosides: 6,7-Dihalo-N-β- and α-Glycosyl-l 4-dihydro-4-oxo-quinoline-3-carboxylic Acids and Derivatives. Synthesis, Antimicrobial and Antiviral Activity

Najim A. Al‐Masoudi, Yaseen A. Al‐Soud, Michael Ehrmann, De Clercq Erik

Article1991

Synthesis and antiviral and cytostatic properties of 3'-deoxy-3'-fluoro- and 2'-azido-3'-fluoro-2',3'-dideoxy-D-ribofuranosides of natural heterocyclic bases

Igor A. Mikhailopulo, Nicolai E. Poopeiko, T. I. Prikota, Grigorii G. Sivets, E. I. KVASYUK, Jan Balzarini, De Clercq Erik

Article1994

Novel Series of TSAO-T Derivatives. Synthesis and Anti-HIV-1 Activity of 4-, 5-, and 6-Substituted Pyrimidine Analogs

Ana San‐Félix, Sonsoles Velázquez, María‐Jesús Pérez‐Pérez, Jan Balzarini, De Clercq Erik, Marı́a-José Camarasa

Article1993

TSAO analogs. 3. Synthesis and anti-HIV-1 activity of 2',5'-bis-O-(tert-butyldimethylsilyl)-.beta.-D-ribofuranosyl 3'-spiro-5"-(4"-amino-1",2"-oxathiole 2",2"-dioxide) purine and purine-modified nucleosides

Sonsoles Velázquez, Ana San‐Félix, María‐Jesús Pérez‐Pérez, Jan Balzarini, De Clercq Erik, Marı́a-José Camarasa

Article1997

ChemInform Abstract: Synthesis and Antiviral Evaluation of N‐β‐D‐Ribosides of Ergot Alkaloids.

Vladimı́r Křen, A. Pískala, Petr Sedmera, Vladimı́r Havlı́ček, Věra Přikrylová, Myriam Witvrouw, De Clercq Erik