Synthesis and Antiviral and Antineoplastic Activities of Some Novel Carbocyclic Guanosine Analogues with a Cyclobutane Ring. — José Manuel Blanco (1999) | RDL Network
Synthesis and Antiviral and Antineoplastic Activities of Some Novel Carbocyclic Guanosine Analogues with a Cyclobutane Ring.
Article 1999 en
Authors
JB
José Manuel Blanco
OC
Olga Caamaño
FF
Franco Fernández
Abstract
1 min read
Cyclobutyl nucleoside analogues containing guanine and 8-azaguanine (compounds 5-10) were prepared from (1R,cis)-3-aminomethyl-2,2-dimethylcyclobutylmethanol (1). All were evaluated as antiviral and antitumoral agents in a variety of assay systems. Compounds 6 and 7 showed a noteworthy activity against a respiratory syncytial virus and compound 10 was moderately active against vaccinia virus. Only compound 5 showed some cytostatic activity.
José E. Rodríguez‐Borges, Franco Fernández, Xerardo García‐Mera, Antonio R. Hergueta, Carmen López, Graciela Andreï, Robert Snoeck, Myriam Witvrounw, Jan Balzarini, De Clercq Erik
M. José Figueira, JoséM. Blanco, Olga Caamaño, Franco Fernández, Xerardo García‐Mera, Carmen López, Graciela Andreï, Robert Snoeck, Elisabeth Padalko, Johan Neyts, Jan Balzarini, De Clercq Erik
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