Synthesis and antiviral activity of some new benzofuran derivatives.

A. PAPADAKI‐VALIRAKI; O. G. TODOULOU; Evangelos Filippatos; Andrew Tsotinis; Shun‐ichi Ikeda; De Clercq Erik

Abstract

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New derivatives of benzofuran were prepared and evaluated for their in vitro activity against a number of DNA and RNA viruses in various cell systems. Compounds 1-(7-dodecyloxy-2-benzofuranyl)ethanone (3c) and 1-(7-tridecyloxy-2-benzofuranyl)ethanone (3d) exhibited a specific activity against respiratory syncytial virus in HeLa and compound [di(2-acetylbenzofuranyl-7-oxy)]-n-propane (5a) against influenza A virus in MDCK.

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