Synthesis and Antiviral Activity of Some C 2 -, C 4 -, and C 6 -Substituted Pyrazolo[3,4-D]Pyrimidine Acyclonucleosides with the Alkylating Chains of ACV, HBG, and ISO-DHPG

Omar Moukha‐Chafiq; Mohamed Labd Taha; Hassan B. Lazrek; Jean‐Jacques Vasseur; De Clercq Erik

doi:10.1080/15257770600793802

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Synthesis and Antiviral Activity of Some C 2 -, C 4 -, and C 6 -Substituted Pyrazolo[3,4-D]Pyrimidine Acyclonucleosides with the Alkylating Chains of ACV, HBG, and ISO-DHPG

Article 2006 en

Authors

OM
Omar Moukha‐Chafiq
MT
Mohamed Labd Taha
HL
Hassan B. Lazrek

Abstract

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A useful route to obtain trisubstituted pyrazolo[3,4-d]pyrimidines 14-17 is described. Those later were coupled with the alkylating agents 18-20 as in ACV, HBG, and iso-DHPG to give, after deprotection, the desired acylonucleosides 33-44. Almost all of the new compounds were evaluated for their inhibitory effects against the replication of various DNA viruses in culture.

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Synthesis and Antiviral Activity of Some C <sub>2</sub> -, C <sub>4</sub> -, and C <sub>6</sub> -Substituted Pyrazolo[3,4-D]Pyrimidine Acyclonucleosides with the Alkylating Chains of ACV, HBG, and ISO-DHPG

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