Synthesis and antiviral activity of novel derivatives of 2'- -C-methylcytidine

Joanna Fogt; Piotr Januszczyk; Grzegorz Framski; Taku Onishi; Kunisuke Izawa; De Clercq Erik; Johan Neyts; Jerzy Boryski

doi:10.1093/nass/nrn306

Abstract

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A series of novel derivatives of 2'-C-beta-methylcytidine, involving nucleosides modified in the "upper part" of the pyrimidine base (N(4)- and/or 5-position), has been synthesized and evaluated for their inhibitory effect on in vitro replication of the hepatitis C virus and the yellow fever virus (both Flaviviridae).

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