Abstract Modified 1,2,6-thiadiazine dioxide acyclonucleosides were synthesized using the silylation method. All the compounds were tested as antiviral agents in a wide variety of assay systems. With two compounds, some activity (20, 35 and 14 μg/mL, respectively) was noted against herpes simplex virus, human cytomegalovirus and varicella-zoster virus.
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