Synthesis and Antiviral Activities of Some New 5-Heteroaromatic Substituted Derivatives of 2'-Deoxyuridine

J. Liu; Arthur Van Aerschot; Ingrid Luyten; Piet Wigerinck; Christophe Pannecouque; Jan Balzarini; De Clercq Erik; Piet Herdewijn

doi:10.1080/15257779508012418

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Synthesis and Antiviral Activities of Some New 5-Heteroaromatic Substituted Derivatives of 2'-Deoxyuridine

Article 1995 en

Abstract

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Abstract Eight new 5-heteroaromatic substituted analogues of 2′-deoxyuridine have been synthesized and evaluated for their inhibitory properties against a panel of different viruses. Several analogues containing a substituted thiophene moiety proved to be highly selective against herpes simplex virus type 1 (HSV-1).

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