Synthesis and anti-HIV Evaluation of Alkyl and Alkoxyethyl Phosphodiester AZT Derivatives
Article 1995 en
Authors
TC
Theodora Calogeropoulou
MK
Maria Koufaki
AT
Andrew Tsotinis
Abstract
1 min read
A series of new AZT conjugates with alkyl and oxyalkyl ether phospholipids was synthesized and evaluated for inhibitory activities against HIV-1 and HIV-2. The alkoxyethyl derivatives 6a-c proved 3- to 5-fold more active against HIV-1 and HIV-2 than the alkyl analogues 6d-f. A trend for higher activity with longer alkyl side-chains was observed. However, the analogues with the shortest chain possessed the most favourable therapeutic index.
Thomas Mavromoustakos, Theodora Calogeropoulou, Maria Koufaki, Antonios Kolocouris, Ioanna Daliani, Costas Demetzos, Zhaoxing Meng, Alexandros Makriyannis, Jan Balzarini, De Clercq Erik
Nicolas Kolocouris, Antonios Kolocouris, George B. Foscolos, George Fytas, Johan Neyts, Elisabeth Padalko, Jan Balzarini, Robert Snoeck, Graciela Andreï, De Clercq Erik
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