Synthesis and an Antiviral Activity Evaluation of Nucleoside 5′-O-(N-acyl) Phosphoramidates

Katarzyna Kulik; Ewa Radzikowska‐Cieciura; Renata Kaczmarek; Janina Baraniak; Wojciech J. Stec; De Clercq Erik; Jan Balzarini; Christophe Pannecouque

doi:10.3851/imp1718

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Synthesis and an Antiviral Activity Evaluation of Nucleoside 5′-O-(N-acyl) Phosphoramidates

Article 2011 en

Abstract

1 min read

loss of compound antiviral potency in the CEM/TK(-) cells suggested an eventual conversion of the test compounds to the free nucleosides prior to further phosphorylation to the active 5´-triphosphate metabolite.

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Synthesis and an Antiviral Activity Evaluation of Nucleoside 5′-<i>O</i>-(<i>N</i>-acyl) Phosphoramidates