Abstract A series of 5′‐ O ‐ acyl derivatives (2a‐e) of 5‐ethyl‐2′‐deoxyuridine (EDU, EtUdR) were prepared by direct acylation of the parent nucleoside 1 in pyridine/ N,N ‐dimethylformamide (DMF). These compounds, designed as prodrugs of 1 , offer a wider range of solubilities and lipophilicities than 1. The antiviral activities (against herpes simplex virus types 1 and 2) of all compounds were determined in primary rabbit kidney (PRK) cell cultures.
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