Synergistic effects of Platelet-derived growth factor-BB and Transforming growth factor-β1 on profibrogenic activities in hepatic stellate cells — Olaf Scherner (2008) | RDL Network
Synergistic effects of Platelet-derived growth factor-BB and Transforming growth factor-β1 on profibrogenic activities in hepatic stellate cells
Article 2008 en
Authors
OS
Olaf Scherner
SM
SK Meurer
EB
Erawan Borkham‐Kamphorst
Abstract
1 min read
Background/Aims: Platelet-derived growth factor (PDGF)-BB and transforming growth factor (TGF)-β1 are important profibrogenic cytokines involved in liver fibrogenesis. They trigger the activation of hepatic stellate cells (HSC) and the synthesis of extracellular matrix (ECM) components, respectively. The pivotal role of both cytokines has been figured out by using antagonistic strategies [1]. It has been previously shown that PDGF-BB may exponentiate profibrogenic TGF-β signaling through a MAP Kinase (MAPK)-mediated modulation of Smad activity [2].
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