Susceptibility of SARS-CoV-2 Omicron Variants to Therapeutic Monoclonal Antibodies: Systematic Review and Meta-analysis

Kaiming Tao; Philip L. Tzou; Sergei L. Kosakovsky Pond; John P A Ioannidis; Robert W. Shafer

doi:10.1128/spectrum.00926-22

Abstract

1 min read

Monoclonal antibodies (MAbs) targeting the SARS-CoV-2 spike protein are among the most effective measures for preventing and treating COVID-19. However, SARS-CoV-2 Omicron variants contain many mutations in their spike receptor-binding domains, the target of all authorized MAbs.

Related publications

Preprint2022

Susceptibility of SARS-CoV-2 Omicron Variants to Therapeutic Monoclonal Antibodies: Systematic Review and Meta-Analysis

Kaiming Tao, Philip L. Tzou, Sergei L. Kosakovsky Pond, John P A Ioannidis, Robert W. Shafer

Article2022

Epistasis at the SARS-CoV-2 Receptor-Binding Domain Interface and the Propitiously Boring Implications for Vaccine Escape

Nash D. Rochman, Guilhem Faure, Yuri I. Wolf, Peter L. Freddolino, Feng Zhang, Eugene V Koonin

Article2023

Health Outcomes and Cost-effectiveness of Monoclonal SARS-CoV-2 Antibodies as Pre-exposure Prophylaxis

Stephanie Popping, Brooke E Nichols, Brent Appelman, Jason J. Biemond, Magda Vergouwe, Frits R. Rosendaal, Marc van der Valk, Godelieve J. de Bree, W. Joost Wiersinga, Emma Birnie, Michiel Schinkel, Matthijs R. A. Welkers, Hans L. Zaaijer, Frans J. Ittersum van, Maarten F. Schim van der Loeff, Marije K. Bomers, Marie José Kersten, Mette D. Hazenberg, Jarom Heijmans, E. Marleen Kemper, Mark de Boer, Renée A. Douma, Marcel van den Berge,

Preprint2021

Epistasis at the SARS-CoV-2 RBD Interface and the Propitiously Boring Implications for Vaccine Escape

Nash D. Rochman, Guilhem Faure, Yuri I. Wolf, Peter L. Freddolino, Feng Zhang, Eugene V Koonin

Article2020

Functional Pangenome Analysis Shows Key Features of E Protein Are Preserved in SARS and SARS-CoV-2

Intikhab Álam, Allan Kamau, Maxat Kulmanov, Łukasz Jaremko, Stefan T. Arold, Arnab Pain, Takashi Gojobori, Carlos M. Duarte