Supplementary Figures S1-S6 from Targeting Adenosine in BRAF-Mutant Melanoma Reduces Tumor Growth and Metastasis

<p>This file contains Supplementary Figure S1A-B, Figure S2A, Figure S3-F, Figure S4A-B, Figure S5A-E and Figure S6A. Figure S1. CD73 expression in melanoma does not associate with survival. Figure S2. Hematopoietic A2AR-deficiency reduces inducible BRAF-mutated tumor growth. Figure S3. A2AR inhibition enhances CD8+ T and NK cell infiltration into the tumor microenvironment. Figure S4. SOX10 expression is present in skin and BRAF-mutated, PTENdeficient tumors. Figure S5. A2AR and BRAF inhibition in combination provides improved tumor control. Figure S6. BRAF and MEK downregulate tumor-derived CD73 expression.</p>