Supplementary Figures S1-S6 from Dsh Homolog DVL3 Mediates Resistance to IGFIR Inhibition by Regulating IGF-RAS Signaling

<p>Supplementary Figures S1-S6. S1: Sensitivity to IGF�1R inhibitor AZ12253801 is influenced by levels of DVL3 protein but not IGF�1R or INSR S2: Effects of HUNK depletion on IGF signalling S3: Sensitivity to IGF�1R inhibition is enhanced by proximal but not distal WNT pathway inhibition S4: Investigating effects of DVL3 on IGF�induced ERK activation in prostate and breast cancer cells S5: ERK activation induced by DVL inhibition is independent of EGFR and IRS�1, and involves complex formation with adaptor proteins Grb2, DAB2 and SOS S6: DVL3 immunohistochemistry</p>