Supplementary Data from Hypoxia-Induced Suppression of Alternative Splicing of MBD2 Promotes Breast Cancer Metastasis via Activation of FZD1

<p>Supplementary Figures: Figure S1. MBD2a and MBD2c exert opposing roles in BrCa cell migration. Figure S2. Hypoxia inhibits SRSF2-mediated MBD2 splicing. Figure S3. MBD2a and MBD2c inversely regulate EMT markers. Figure S4. DNA methylation controls MBD2-mediated FZD1 transcription. Figure S5. The effect of MBD2a and MBD2c on breast tumor growth in vivo. Supplementary Tables: Table S1, DAVID analysis of the co-regulated genes. Table S2, Metastasis-related Genes with altered expression according to RNA-seq data involved in cell migration. Table S3, DAVID analysis of the co-regulated and co-bound genes. Table S4, Primers used for quantification of mRNA and genome DNA. Table S5, Information of antibody, chemical reagent, cell line and software.</p>