Supplemental Materials and Figures from Heme-oxygenase-1 Production by Intestinal CX3CR1<sup>+</sup> Macrophages Helps to Resolve Inflammation and Prevents Carcinogenesis

<p>Table 1: Experimental procedures in mice Primers used in RT-PCRFigure S1: Colitis-associated carcinogenesis is more severe in CX3CR1GFP/GFP (KO mice) Figure S2: Macrophages from CX3CR1GFP/GFP mice are able to produce and sense IL10 Figure S3: CX3CR1 signaling induces STAT3 phosphorylation Figure S4: Sequencing of fecal microbiota of CX3CR1GFP/ (WT) and CX3CR1GFP/GFP (KO) mice (Figure S5: Effect of pharmacological treatments with the HMOX-1 inhibitor znPP (red) or the HMOX-1 stimulator coPP (blue) on the inflammation induced by 1 administration of DSS in WT mice Figure S6: Hematoxylin and eosin staining of CX3CR1GFP/ (WT) and CX3CR1GFP/GFP (KO) colon treated with coPP Figure S7: Double immunofluorescence on sections of adenomatous polyps from mice undergoing the AOM-DSS protocol</p>