Superoxide‐dependent formation of hydroxyl radicals in the presence of iron salts

William D. Flitter; D. A. Rowley; Barry Halliwell

doi:10.1016/0014-5793(83)80602-4

Superoxide‐dependent formation of hydroxyl radicals in the presence of iron salts

FEBS Letters 158(2): 310-312

Article 1983 English

Abstract

1 min read

In the presence of physiological concentrations of iron(III) salts, superoxide radical and hydrogen peroxide can interact to form the highly‐damaging hydroxyl radical. No specific added ‘chelator’ of iron salts is necessary for this reaction to occur.

Related publications

Article1983

Formation of Hydroxyl Radicals from Hydrogen Peroxide and Iron Salts by Superoxide- and Ascorbate-Dependent Mechanisms: Relevance to the Pathology of Rheumatoid Disease

D. A. Rowley, Barry Halliwell

Clinical Science

Article1981

Superoxide-dependent formation of hydroxyl radicals in the presence of iron salts. Detection of ‘free’ iron in biological systems by using bleomycin-dependent degradation of DNA

John M.C. Gutteridge, D. A. Rowley, Barry Halliwell

Biochemical Journal

Article1982

Superoxide-dependent formation of hydroxyl radicals and lipid peroxidation in the presence of iron salts. Detection of ‘catalytic’ iron and anti-oxidant activity in extracellular fluids

John M.C. Gutteridge, David A. Rowley, Barry Halliwell

Biochemical Journal

Article1985

Use of desferrioxamine as a ‘probe’ for iron-dependent formation of hydroxyl radicals

Barry Halliwell

Biochemical Pharmacology

Article1983

Superoxide-dependent and ascorbate-dependent formation of hydroxyl radicals in the presence of copper salts: A physiologically significant reaction?

D. A. Rowley, Barry Halliwell

Archives of Biochemistry and Biophysics

Superoxide‐dependent formation of hydroxyl radicals in the presence of iron salts

Abstract

Discussion(0)

Related publications

Formation of Hydroxyl Radicals from Hydrogen Peroxide and Iron Salts by Superoxide- and Ascorbate-Dependent Mechanisms: Relevance to the Pathology of Rheumatoid Disease

Superoxide-dependent formation of hydroxyl radicals in the presence of iron salts. Detection of ‘free’ iron in biological systems by using bleomycin-dependent degradation of DNA

Superoxide-dependent formation of hydroxyl radicals and lipid peroxidation in the presence of iron salts. Detection of ‘catalytic’ iron and anti-oxidant activity in extracellular fluids

Use of desferrioxamine as a ‘probe’ for iron-dependent formation of hydroxyl radicals

Superoxide-dependent and ascorbate-dependent formation of hydroxyl radicals in the presence of copper salts: A physiologically significant reaction?