Sugar‐Selective Enrichment of a <scp>D</scp>‐Glucose‐Substituted Ruthenium Bipyridyl Complex Inside HepG2 Cancer Cells

Michael Gottschaldt; Ulrich Sigmar Schubert; Sven Rau; Shigenobu Yano; Johannes G. Vos; Torsten Kroll; Joachim H. Clement; Ingrid Hilger

doi:10.1002/cbic.200900769

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Sugar‐Selective Enrichment of a <scp>D</scp>‐Glucose‐Substituted Ruthenium Bipyridyl Complex Inside HepG2 Cancer Cells

Article 2010 en

Abstract

1 min read

Ru sugar balls: RuII bipyridyl complexes bearing different sugar units were synthesized. Incubation of these compounds with HepG2 cells shows for the first time that cellular uptake of equally substituted ruthenium bipyridyl complexes can be controlled by the type of sugar attached. Preferential internalization of the D-glucose-bearing complex was observed and verified by confocal laser scanning microscopy (CLSM) and flow cytometry.

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